Mucosal Barrier Injury Central-Line–Associated Bloodstream Infections: What is the Impact of Standard Prevention Bundles?

Central line-associated bloodstream infections in neonates with gastrointestinal conditions: developing a candidate definition for mucosal barrier injury bloodstream infections.

OBJECTIVE To develop a candidate definition for central line-associated bloodstream infection (CLABSI) in neonates with presumed mucosal barrier injury due to gastrointestinal (MBI-GI) conditions and to evaluate epidemiology and microbiology of MBI-GI CLABSI in infants. DESIGN Multicenter retrospective cohort study. SETTING Neonatal intensive care units from 14 US children's hospitals and p...

Impact of bundle for central line associated bloodstream infections prevention

Introduction / objectives Bundles have been developed to facilitate the application of infection control guidelines. Because in our institution the rates of central line associated bloodstream infections (CL-BSI) were above the international standards it was decided to implement a specific bundle through a multimodal approach. The aim of this study was to describe the strategy of bundle impleme...

Prevention of Central Line-Associated Bloodstream Infections: Brief Update Review

The impact of hospital-acquired bloodstream infections.

Nosocomial bloodstream infections are a leading cause of death in the United States. If we assume a nosocomial infection rate of 5%, of which 10% are bloodstream infections, and an attributable mortality rate of 15%, bloodstream infections would represent the eighth leading cause of death in the United States. Because most risk factors for dying after bacteremia or fungemia may not be changeabl...

Prevention of intravascular catheter-related bloodstream infections.

solution available in clinical settings, especially when current Centers for Disease Control and Prevention guidelines state that only solutions of PPD containing 5 TU/0.1 mL should be used.1 We have discontinued the 250 TU formulation in our institution. We urge caution in the interpretation of tuberculin tests and suggest careful examination of the strength of the solution before administration.